Cold Agglutinin Disease (CAD) — Practice Quiz

In classic Cold Agglutinin Disease, hemolysis is primarily driven by:

Which DAT (Direct Antiglobulin Test) pattern most strongly supports CAD?

A key lab pitfall in CAD is that cold agglutination can cause:

Which clinical finding is most characteristic of CAD (vs warm AIHA)?

Which statement about treatment is most accurate for classic CAD?

In CAD, the pathogenic antibody is typically IgM with complement fixation.

A positive DAT for IgG only (with negative C3) strongly supports CAD.

Thermal amplitude is clinically relevant because higher thermal amplitude tends to correlate with more severe disease.

Warm AIHA and CAD have identical expected responses to corticosteroids.

If transfusion is needed in CAD, using a blood warmer and keeping the patient warm are practical measures.